Practical application of vaccines under field conditions
Innovation in manufacturing will drive quality, supply, and cost effectiveness
❖ Improved Quality Control Measures
❖ Trained personnel
❖ In process and final QC checks
❖ Documentation of procedures
❖ Process validation
❖ Environmental control
❖ Aseptic manufacturing
❖ Pharmacovigilance
❖ Internal audits
❖ External audits
Innovation in manufacturing will drive quality, supply, and cost effectiveness
❖ Technology advances in manufacturing
❖ Isolator technology
❖ No direct contact with the
product
❖ GMP compliant
❖ Better product quality
❖ High throughput technology
❖ Streamline processes for better
time management
Innovation in manufacturing will drive quality, supply, and cost effectiveness
❖ Technology advances in manufacturing
❖ Single-use technology
❖ Technology advances could increase production costs
But
❖ Intrinsic vaccine properties can be optimized for better
production efficiency
❖ Reduction in cost to end user
❖ Better waste management
❖ Upscaled production volumes
❖ Fully automated process control for
repeatability
Innovation in manufacturing will drive quality, supply, and cost effectiveness
Registered products currently manufactured for MSD Intervet
Bovi-tect P
- M. haemolytica leukotoxin for pasteurellosis
Bovi-tect PI
- M. haemolytica leukotoxin combined with bovine herpes virus 1 (IBR)
Bovi-tect III
- M. haemolytica leukotoxin combined with IBR virus and bovine viral diarrhea virus (BVD)
Respiravax
- M. haemolytica leukotoxin combined with inactivated IBR, BVD and PI3
Lumpyvax
Modified, live lumpy skin disease virus vaccine
Recently Registered Vaccines
Recently Registered Vaccines
Recently Registered Vaccines
Multisomni (G4357)
Multisomni an adjuvanted multi-component vaccine for the active immunisation of healthy cattle against respiratory pneumonia caused by Pasteurella multocida type A, P. multocida type D and Histophilus somni.
BEF-TECT (3-day stiff-sickness) (G4356)
BEF-TECT is an adjuvanted live attenuated Bovine ephemeral fever (BEF) virus vaccine for the prophylactic immunization against the economically important disease of dairy cows, bulls and beef herds.
Recently Registered Supplements
Micromin B 500 (G4382)
Manganese Zinc Selenium Chromium Copper
Micromin O 100 (G4384)
Manganese Zinc Selenium
Micromin O 100 Plus (G4383)
Manganese Zinc Selenium Copper
Vaccines
Inactivated / Killed vaccines
Antigens are chemically inactivated
Live vaccines
Antigens are modified / attenuated in order to reduce pathogenicity but retain immunogenicity
Immunity and Immunisation
Aim of an ideal vaccine:
- To produce the same immune protection which usually follows natural infection, without causing disease
- To generate long-lasting immunity
- To interrupt spread of infection
Vaccine failures
Primary failure: an individual fails to make an adequate immune response to the initial vaccination
Vaccine Response/Failure to Respond
Vaccine failures
- Primary failure: an individual fails to mount an adequate immune response to the initial vaccination
- Secondary failure: an individual mounts an adequate immune response initially but then immunity wanes over time – a feature of most inactivated vaccines, hence the need for boosters
Vaccine failures
- Primary failure: an individual fails to make an adequate immune response to the initial vaccination
- Secondary failure: an individual makes an adequate immune response initially but then immunity wanes over time (a feature of most inactivated vaccines, hence the need for boosters)
- Compromised immune system
BVD –30 Days post infection
Alhydrogel damage by freezing
Kurzątkowski et al., 2018
PRECAUTIONS
- Follow standard sterile procedures during administration of injections.
- Consult a veterinarian before use.
- Dispose of all containers and all unused contents in accordance with the local law.
- Do not mix this product with any other vaccines or medicines.
DIRECTIONS FOR USE
- Use only as directed.
- Shake gently before use by inverting the vial several times.
- Use the entire content of the vial once opened.
- Use sterile needles and syringes.
- Inject cattle subcutaneously on the side of the neck. DO NOT deviate from the recommended route and injection site location.
Dirty needles
DIRECTIONS FOR USE
- Use only as directed.
- Shake gently before use by inverting the vial several times.
- Use the entire content of the vial once opened.
- Use sterile needles and syringes.
- Inject cattle subcutaneously on the side of the neck. DO NOT deviate from the recommended route and injection site location.