Practical application of vaccines under field conditions presented by Dr Angela Buys of Design Biologix | 27 November 2019 | Octavoscene Feedlot Workshop

Practical application of vaccines under field conditions

Innovation in manufacturing will drive quality, supply, and cost effectiveness

❖  Improved Quality Control Measures

❖   Trained personnel

❖   In process and final QC checks

❖   Documentation of procedures

❖   Process validation

❖   Environmental control

❖   Aseptic manufacturing

❖   Pharmacovigilance

❖   Internal audits

❖   External audits

Innovation in manufacturing will drive quality, supply, and cost effectiveness

❖  Technology advances in manufacturing

❖  Isolator technology

❖   No direct contact with the

      product

❖   GMP compliant

❖   Better product quality

High throughput technology

❖   Streamline processes for better

      time management

Innovation in manufacturing will drive quality, supply, and cost effectiveness

❖  Technology advances in manufacturing

❖  Single-use technology

❖  Technology advances could increase production costs

But

Intrinsic vaccine properties can be optimized for better 

     production efficiency

Reduction in cost to end user

Better waste management

Upscaled production volumes

Fully automated process control for

      repeatability

Innovation in manufacturing will drive quality, supply, and cost effectiveness

 

 

 

 

 

 

 

 

Registered products currently manufactured for MSD Intervet

Bovi-tect P

  1. M. haemolytica leukotoxin for pasteurellosis

Bovi-tect PI

  1. M. haemolytica leukotoxin combined with bovine herpes virus 1 (IBR)

Bovi-tect III

  1. M. haemolytica leukotoxin combined with IBR virus and bovine viral diarrhea virus (BVD)

Respiravax

  1. M. haemolytica leukotoxin combined with inactivated IBR, BVD and PI3

Lumpyvax

Modified, live lumpy skin disease virus vaccine

 

Recently Registered Vaccines

 

Recently Registered Vaccines

Recently Registered Vaccines

Multisomni (G4357)

Multisomni an adjuvanted multi-component vaccine for the active  immunisation of healthy cattle against respiratory pneumonia caused by Pasteurella multocida type A, P. multocida type D and Histophilus somni.

BEF-TECT (3-day stiff-sickness) (G4356)

BEF-TECT   is   an   adjuvanted   live   attenuated   Bovine ephemeral fever (BEF) virus vaccine for the prophylactic immunization  against  the  economically  important disease of dairy cows, bulls and beef herds.

Recently Registered Supplements

Micromin B 500 (G4382)

Manganese    Zinc    Selenium    Chromium    Copper

Micromin O 100 (G4384)

Manganese    Zinc    Selenium

Micromin O 100 Plus (G4383)

Manganese    Zinc     Selenium     Copper

Vaccines

Inactivated / Killed vaccines

Antigens are chemically inactivated

Live vaccines

Antigens are modified / attenuated in order to reduce pathogenicity but retain immunogenicity

Immunity and Immunisation

Aim of an ideal vaccine:

  • To produce the same immune protection which usually follows natural infection, without causing disease
  • To generate long-lasting immunity
  • To interrupt spread of infection

Vaccine failures

Primary failure: an individual fails to make an adequate immune response to the initial vaccination

 

Vaccine Response/Failure to Respond

Vaccine failures

  • Primary failure: an individual fails to mount an adequate immune response to the initial vaccination
  • Secondary failure: an individual mounts an adequate immune response initially but then immunity wanes over time – a feature of most inactivated vaccines, hence the need for boosters

 

Vaccine failures

  • Primary failure: an individual fails to make an adequate immune response to the initial vaccination
  • Secondary failure: an individual makes an adequate immune response initially but then immunity wanes over time (a feature of most inactivated vaccines, hence the need for boosters)
  • Compromised immune system

 

BVD –30 Days post infection

 

Alhydrogel damage by freezing

Kurzątkowski et al., 2018

 

PRECAUTIONS

  • Follow standard sterile procedures during administration of injections.
  • Consult a veterinarian before use.
  • Dispose of all containers and all unused contents in accordance with the local law.
  • Do not mix this product with any other vaccines or medicines.

DIRECTIONS FOR USE

  • Use only as directed.
  • Shake gently before use by inverting the vial several times.
  • Use the entire content of the vial once opened.
  • Use sterile needles and syringes.
  • Inject cattle subcutaneously on the side of the neck. DO NOT deviate from the recommended route and injection site location.

 

 

 

Dirty needles

 

 

 

 

DIRECTIONS FOR USE

  • Use only as directed.
  • Shake gently before use by inverting the vial several times.
  • Use the entire content of the vial once opened.
  • Use sterile needles and syringes.
  • Inject cattle subcutaneously on the side of the neck. DO NOT deviate from the recommended route and injection site location.